Granuloma annulare (GA) is a benign inflammatory dermatosis. T. Colcott Fox first described granuloma annulare in ; however, not until. Granuloma annulare. Authoritative facts about the skin from DermNet New Zealand. Granuloma annulare often causes a slightly raised patch on your skin that has a noticeable (and sometimes scaly) border.

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See My Options close. By using this site, you agree to anylar Terms of Use and Privacy Policy. Bolognia JL, et al. Nevertheless, many patients remain troubled by the appearance and persist in seeking treatment.

J Am Acad Dermatol ; Niacinamide has been used and is reasonably safe, even at high doses. The eruption spontaneously resolved but then recurred.

Most cases of granuloma annulare clear up without treatment spontaneous resolution.

The cause of granuloma annulare is unknown, but it has been reported to follow trauma, malignancy, viral infections including human immunodeficiency virus [HIV], Epstein-Barr virus, and herpes zosterinsect bites, and tuberculosis skin tests. The first treatment you try may not work.

The following treatments have been reported to help at least some cases of disseminated granuloma annulare. The primary skin lesion usually is grouped papules in an enlarging annular shape, with color ranging from flesh-colored to erythematous.

Successful outcome of cryosurgery in patients with granuloma annulare.

Granuloma annulare is a rash that often looks like a ring of small pink, purple or skin-coloured bumps. Granulooma most cases, granuloma annulare isn’t itchy or painful, so no treatment is necessary. Hansen’s disease leprosy also has erythematous annular plaques with associated scaling, alopecia, and anesthesia.

Granuloma Annulare – NORD (National Organization for Rare Disorders)

Disseminated granuloma annulare may be treated with one of several systemic therapies such as anularr, retinoids, niacinamide, antimalarials, psoralen plus ultraviolet A therapy, fumaric acid esters, tacrolimus, and pimecrolimus. It usually affects adults. Last accessed Feb 28, Otherwise, this disease seems to occur about equally in people of different races and parts of the world.


Elevated liver function test results.

Granuloma annulare | DermNet NZ

Rarely, granuloma annulare may appear as a firm nodule under the skin of the arms or legs. Skip to main content. J Eur Acad Dermatol Venereol. Four had complete resolution, three had partial response. Information on current clinical trials is posted on the Internet at www. Kyrle disease Reactive perforating collagenosis Elastosis perforans serpiginosa Perforating folliculitis Acquired perforating dermatosis.

The content of the website and databases of the National Organization for Rare Disorders NORD is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD. Two patients had healing of inflammation.

Treatment is not always successful. Keratoderma climactericum Paraneoplastic keratoderma Acrokeratosis paraneoplastica of Bazex Aquagenic keratoderma Drug-induced keratoderma psoriasis Keratoderma blennorrhagicum keratosis: Harth W, Linse R. Unfortunately, there’s no really effective treatment for granuloma annulare.

Localized granuloma annulare is associated with insulin-dependent diabetes mellitus. One had complete resolution, one was resolving. Granuloma annulare is a delayed hypersensitivity reaction to some component of the dermis. The most common form is localized granuloma annulare. Perforating grankloma annulare is rare and occurs most often in children and young adults. References Howard A and White, Jr.

Vitamin E, IU daily. Four had complete remission, three had partial remission. Subcutaneous granuloma annulare is diagnosed primarily in children two to five grabuloma of age. Because localized granuloma annulare is self-limited, no treatment other than reassurance may be necessary.

TABLE 1 Summary of Studies on Treatment of Disseminated Granuloma Annulare Treatment type Number of patients Dosage and duration Outcome Side effects Dapsone Steiner, 19 10 mg daily for 2 granulma 18 weeks Four had complete resolution, three had partial response Headache or weakness Czarnecki, 20 6 mg daily for 4 to 12 weeks All resolved Fatigue Saied, 21 2 to mg daily for 4 granyloma 44 weeks One had anklar resolution, one was resolving None Isotretinoin Accutane Schleicher, 22 1 40 mg once to twice daily for 12 weeks 90 percent resolution Dry lips, elevated triglyceride levels Tang, 23 1 30 to 50 mg daily for 16 weeks Complete response None Buendia-Eisman 24 1 50 mg daily graanuloma eight weeks 90 percent resolution None Schleicher, 25 7 40 mg daily for 10 weeks percent response; three recurred after initial clearing, and drug discontinued Elevated liver function test results Etretinate not available in the U.


Treatment of generalized granuloma annulare with dapsone. Eruptive granulona is characterized by the development of clusters of elevated bumps papules over the entire body. See the DermNet NZ bookstore. Most people develop this type, which causes a raised ring-shaped patch on the skin. Symptoms This skin condition rarely causes symptoms, such as pain or itch. Mayo Clinic does not endorse companies or products. Granuloma annulare is a benign skin condition that typically consists of grouped papules in an enlarging annular shape.

It may return months or years after it clears. Perforating granuloma annulare is characterized by bumps or pustules that develop a yellow center.

Rare Disease Database

Infliximab Remicadea tumor necrosis factor B inhibitor, demonstrated a positive outcome in a patient with recalcitrant disseminated granuloma annulare. Nevertheless, liver toxicity is an important adverse effect, and hepatic transaminase levels should be monitored during treatment.

Many of these patches are reddish in color Abut they can also granuloja pink, violet, or skin-colored B.